Shin-Etsu AQOAT®
Shin-Etsu AQOAT®
(Hypromellose Acetate Succinate)
Shin-Etsu AQOAT® (hypromellose acetate succinate) is our second enteric coating material and it was developed for aqueous coating. Shin-Etsu AQOAT® was approved as a pharmaceutical excipient in Japan in 1987, and then in the United States and several European countries in 2001. In an aqueous system, a suspension containing Shin-Etsu AQOAT® (fine powder), triethyl citrate as a plasticizer, talc as an anti-tacking agent, and sodium lauryl sulfate as a wetting agent is typically used.
Shin-Etsu AQOAT® also shows excellent performance when it is used as a carrier for solid dispersions in order to enhance solubility of poorly soluble drugs.
Shin-Etsu AQOAT® Enteric Coating Agent (Aqueous System & Solvent System)
(Hypromellose Acetate Succinate; NF)
| Grade | pH Solubility | Application Form in Coating Operation | |
|---|---|---|---|
| AS | LF* | ≧5.5 | Aqueous Dispersion |
| MF* | ≧6.0 | ||
| HF* | ≧6.8 | ||
| LG | ≧5.5 | Organic Solvent | |
| MG | ≧6.0 | ||
| HG | ≧6.8 |
Note: * F is fine powder grade (av. particle size about 5μm).